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Augusto Sola, M.D.

Publications

Dr. Sola has written two text books in Spanish in the field of Neonatal Medicine.

Books

The first one was in 1987, titled “Cuidados Intensivos Neonatales, Fisiopatologia and Terapeutica”. This book was extremely important in the developing field of newborn care, mostly in Latin American countries, in an era of no internet, e-mails or faxes. The second one is a two volume book, written with his wife, Marta R. Rogido MD. It is entitled “Cuidados Especiales del Feto y el Recien Nacido” (Special Care of the Fetus and Newborn), published in the year 2001 and is currently out of print. Dr Sola is currently writing two neonatal books in Spanish language: One is a comprehensive, multi author text book, with more than 60 authors from various countries and more than 1,500 pages, which he is editing, (“CUIDADOS NEONATALES: DESCUBRIENDO LA VIDA DE UN RECIÉN NACIDO ENFERMO” – ‘Neonatal Care: Discovering the life of a sick newborn’). It is planned that will be in print by EDIMED in late 2009 or early 2010.
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The other book is a manual of 500 pages: “Dialogues in Neonatology: Learning from the Questions”, being written solely by him. Scheduled to be in print July 2009, by EDIMED. cn

Dr. Sola also has many chapters in neonatal and pediatric textbooks written in the USA, Argentina, Chile, Mexico and other nations. In the field of Neonatal Medicine, Dr. Sola has over 80 publications in peer reviewed journals, both in basic research and in clinical topics. They can all be found in his CV. His most important recent publications have focused in three topics:

  1. Severe hypoxemic respiratory failure in the newborn, exploring the use of oral sildenafil (Viagra).
  2. Mechanisms of injury and protection in the developing brain.
  3. Improving outcomes by changing the practice of oxygen administration and pulse oximetry monitoring.

The recent most important publications in peer reviewed journals in those three areas of neonatal medicine include:

Recent Publications

  1. Sola, A. Turn off the lights and the oxygen, when not needed:  phototherapy and oxidative stress in the neonate.  JPediatr (Rio J). 2007;83(4):293-296
  2. Bouzas L, Bauer G, Novali L, Dilger A, Galina L, Falbo J, Díaz González L, Manzitti J, Sola A. Retinopathy of prematurity in the XXI century in a developing country: an emergency that should be resolved. An Pediatr (Barc). 2007 Jun;66(6):551-8
  3. Sola A, Dieppa FD, Rogido MR. An evident view of evidence-based practice in perinatal medicine: absence of evidence is not evidence of absence. J Pediatr (Rio J). 2007 Sep-Oct;83(5):395-414
  4. Sola A, Peng H, Rogido M, Wen TC. Animal models of neonatal stroke and response to erythropoietin and cardiotrophin-1. Int J Dev Neurosci. 2008 Feb;26(1):27-35.
  5. Sola A, Rogido M. Iron, oxidant injury, and practice choices in preterm infants. J Pediatr. 2008 Feb;152(2):295-6;
  6. Castillo A, Sola A, Baquero H, Neira F, Alvis R, Deulofeut R, Critz A. Pulse oxygen saturation levels and arterial oxygen tension values in newborns receiving oxygen therapy in the neonatal intensive care unit: is 85% to 93% an acceptable range? Pediatrics. 2008 May;121(5):882-9
  7. Sola A. Oxygen for the preterm newborn: one infant at a time. Pediatrics. 2008 Jun;121(6):1257
  8. Sola A. Oxygen in neonatal anesthesia: friend or foe? Curr Opin Anaesthesiol. 2008 Jun;21(3):332-9.
  9. Sola A, Saldeño YP, Favareto V. Clinical practices in neonatal oxygenation: where have we failed? What can we do? J Perinatol. 2008 May;28 Suppl 1:S28-34.
  10. Various and Sola A. (“Grupo de Trabajo Colaborativo Multicéntrico para la Prevención de la Ceguera en la Infancia por Retinopatía del Prematuro”)  Recommendations for Retinopathy of Prematurity screening in at-risk populations  Arch Argent Pediatr. 2008 Feb;106(1):71-6
  11. Sola A, Golombek SG, Baquero H, Borbonet D, Cabañas F, Fajardo C, Goldsmit G, Lemus L, Miura E, Pellicer A, Pérez JM, Rogido M, Zambosco G, van Overmeire B: First SIBEN clinical consensus: diagnostic and therapeutic approach to patent ductus arteriosus in premature newborns. An Pediatr (Barc). 2008 Nov;69(5):454-81.
  12. Bui T, Sequeira J, Wen TC, Sola A, Higashi Y, Kondoh H, Genetta T :  ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia. PLoS ONE. 2009;4(2):e4373. Epub 2009 Feb 4.

Editorials / Commentary

  1. Postnatal Steroids: Short-term gain, long-term pain? Neil N. Finer, MD, Alissa Craft, DO, MBA, Yvonne E. Vaucher, MD, MPH, Reese H. Clark, MD and Augusto Sola MD J Pediatr 2000:137:9-13
  2. An evident view of evidence-based practice in perinatal medicine: absence of evidence is not evidence of absence. Augusto Sola, Fernando Dominguez Dieppa, Marta R. Rogido J Pediatr (Rio J). 2007;83(5): 395-414. (Evidence-based medicine, number needed to treat, randomized trials, outcome variables, treatment effects, critical reading, statistical significance.)
  3. Sola, A. Turn off the lights and the oxygen, when not needed: phototherapy and oxidative stress in the neonate. J Pediatr (Rio J). 2007 Jul-Aug;83(4):293-6.Click here to read

Mechanisms of injury and protection in the developing brain.

  1. Sola A, Piecuch R. Prevalence of cerebral palsy: estimations, calculations and neonatal care. Pediatrics. 1994 Jan;93(1):152-3.
  2. Sola A Berrios M, Gregory A, Ferriero D. Fructose-1,6-bisphosphate after hypoxic ischemic injury is protective to the neonatal rat brain. Brain Res. 1996 25;741(1-2):294-9
  3. Westmark KD, Barkovich AJ, Sola A, Ferriero D, Partridge JC. Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report. AJNR Am J Neuroradiol. 1995;16(4):685-92.
  4. Barkovich AJ, Westmark K, Partridge C, Sola A, Ferriero DM. Perinatal asphyxia: MR findings in the first 10 days. AJNR Am J Neuroradiol. 1995;16(3):427-38.
  5. Barkovich AJ. MR contrast enhancement of the normal neonatal brain. AJNR Am J Neuroradiol. 1997;18(9):1713-7
  6. Van Bel F, Sola A, Roman C, Rudolph AM. Role of nitric oxide in the regulation of the cerebral circulation in the lamb fetus during normoxemia and hypoxemia. Biol Neonate. 1995;68(3):200-10
  7. Van Bel, Sola A, Rudolph AR. Perinatal regulation of the cerebral circulation: role of nitric oxide and prostaglandins. Pediatr Res. 1997;42(3):299-304
  8. Barkovich AJ. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. AJNR Am J Neuroradiol. 1998;19(1):143-9
  9. Finer N, Craft A, Vaucher Y, Clark R, Sola A. Postnatal Steroids: Short Term Gain, Long Term Pain? J Pediatr, 2000 July; 137 (1): 9-13.
  10. Gressens P, Sola A. Environmental factors and disturbances of brain development. Semin Neonatol. 200;6(2):185-94.
  11. Gressens P, Rogido M, Paindaveine B, Sola A. The Impact of Frequent Neonatal Intensive Care Practices on the Developing Brain. J Pediatr,140:646-653, 2002.
  12. Rogido, M, Husson I, Bonnier C, Lallemand MC, Merienne C, Gregory GA, Sola A, Gressens P. Fructose-1, 6 biosphate prevents excitotoxic neuronal cell death in the neonatal mouse brain. Brain Res Dev Brain Res, Feb;140:287-297, 2003.
  13. Baserga MC, Gregory GA, Sola A. Cerebrovascular Response in Small Preterm Infants during Routine Nursery Gavage Feedings. Biol Neonate, 83:12-18, 2003.
  14. Wen TC, Rogido M, Gressens P, Sola A. A reproducible experimental model of focal cerebral ischemia in the neonatal rat. Brain Research Protocols, 13:76-83, 2004.
  15. Wen, TC, Rogido, M, Genetta, T, Sola, A. Permanent focal cerebral ischemia activates erythropoietin receptor I in the neonatal rat brain. Neurosci Lett, 355(3):165-168, 2004.
  16. Valerie Boss, Augusto Sola, Tong-Chun Wen, Michael J. Decker. Mild Intermittent Hypoxis Does Not Induce Stress Responses in the Neonatal Rat Brain. Biology of the Neonate 2005;88:313-320
  17. Sola A, Rogido M, Lee B, Genetta T, Wen TC. Erythropoietin after Focal Cerebral Ischemia Activates the Jaanus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats. Pediatr Res, Apr;57(4):481-7, 2005.
  18. Sola A, Wen T-C, Hamrick S, Ferriero DM. Potential for Protection and Repair following Injury to the Developing Brain: A Role for Erythropoietin? Pediatr Res, May; 57(5), part 2:110R-117R, 2005.
  19. Baserga M, Bertolotto C, Sola A. Different Doses of Dopamine have heterogeneous effects on Cerebral Hemodynamics and Dopamine Receptors in Young Rabbits as measured with Near-Infrared Spectroscopy. Biol Neonate, Jan 14;87(4):229-235, 2005.
  20. Deulofeut R, Sola A. Injury to the Developing Brain in Term and Pre-Term Infants: Mechanisms of Injury and Potential for Prevention and Repair. Journal of The Arab Neonatology Forum, 2: 34-47; 2005.
  21. Thomas Genetta, Ben H. Lee, Augusto Sola. Low doses of ethanol and hypoxia administered together act synergistically to promote the death of cortical neurons. Journal of Neuroscience Research, 2006;851(1): 131-138
  22. Lee Ben H., Wen Tong-Chun, Rogido Marta, Sola Augusto. Glucocorticoid Receptor Expression in the Cortex of the Neonatal Rat Brain with and without Focal Cerebral Ischemia. Neonatology 2007;91:12-19
  23. Baud Oliver, Sola Augusto Corticosteroids in perinatal medicine: How to imporve outcomes without affecting the developing brain?
  24. Gender Differences in Long-Term Beneficial Effects of Erythropoietin Given After Neonatal Stroke in Postnatal Day-7 Rats. T.C. Wen, M. Rogido, H. Peng, T. Genetta, J. Moore and A. Sola Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA Neuroscience 139 (2006) 803-811

Oxygen and its consequences. Improving outcomes by changing the practice of oxygen administration and pulse oximetry monitoring.

  1. Flynn JT, Sola A, Good WV, Phibbs RH. Screening for retinopathy of prematurity — a problem solved? Pediatrics. 1995 May;95(5):755-7
  2. Chow LC, Wright KW, Sola A: Can changes in clinical practice decrease the incidence of severe retinopathy of Prematurity in Very Low Birth Weight Infants? Pediatrics, Feb: 111(2):339-45, 2003.
  3. Sola A, Chow, L, Rogido M: Retinopathy of Prematurity and Oxygen Therapy: A Changing Relationship. An Pediatr (Barc), Jan;62(1):48-63, 2005.
  4. Sola A, Chow L, Rogido M: Pulse oximetry in neonatal care in 2005. A comprehensive state of the art review. An Pediatr (Barc), Mar;62(3):266-281, 2005.
  5. Augusto Sola, MD, Richard Deulofeut, MD, MPH: Oxygen and oxygenation in the delivery room. The Journal of Pediatrics, Volume 148, Issue 4, Pages 564-565 (April 2006
  6. Deulofeut R, Critz A, Adams-Chapman I, Sola A: Avoiding hyperoxia in infants< 1250 g is associated with improved short-and long-term outcomes. Journal of Perinatology (2006) 26, 700-705
  7. Sola A, Rogido MR, Deulofeut R.: Oxygen as a neonatal health hazard: Call for Détente in Clinical Practice. Acta Paediatr. 2007 Jun;96(6):798-800.
  8. Treatment-by-gender effect when aiming to avoid hyperoxia in preterm infants in the NICU. Richard Deulofeut, Golde Dudell, Augusto Sola. Acta Paediatr. 2007 Jul;96(7):990-4.
  9. Retinopathy of prematurity in the XXI century in a developing country: an emergency that should be resolved. Bouzas L, Bauer G, Novali L, Dilger A, Galina L, Falbo J, Díaz González L, Manzitti J, Sola A. An Pediatr (Barc). 2007 Jun;66(6):551-8.
  10. Ophthalmologic and neonatal guidelines for ROP screening and treatment in Latin American Countries (October/2007) VISION 2020 The Right to Sight AMERICAS
  11. Sola, A. Turn off the lights and the oxygen, when not needed:  phototherapy and oxidative stress in the neonate.  JPediatr (Rio J). 2007;83(4):293-296
  12. Bouzas L, Bauer G, Novali L, Dilger A, Galina L, Falbo J, Díaz González L, Manzitti J, Sola A. Retinopathy of prematurity in the XXI century in a developing country: an emergency that should be resolved. An Pediatr (Barc). 2007 Jun;66(6):551-8
  13. Sola A, Rogido M. Iron, oxidant injury, and practice choices in preterm infants. J Pediatr. 2008 Feb;152(2):295-6;
  14. Castillo A, Sola A, Baquero H, Neira F, Alvis R, Deulofeut R, Critz A. Pulse oxygen saturation levels and arterial oxygen tension values in newborns receiving oxygen therapy in the neonatal intensive care unit: is 85% to 93% an acceptable range? Pediatrics. 2008 May;121(5):882-9
  15. Sola A. Oxygen for the preterm newborn: one infant at a time. Pediatrics. 2008 Jun;121(6):1257
  16. Sola A. Oxygen in neonatal anesthesia: friend or foe? Curr Opin Anaesthesiol. 2008 Jun;21(3):332-9.
  17. Sola A, Saldeño YP, Favareto V. Clinical practices in neonatal oxygenation: where have we failed? What can we do? J Perinatol. 2008 May;28 Suppl 1:S28-34.
  18. Various and Sola A. (“Grupo de Trabajo Colaborativo Multicéntrico para la Prevención de la Ceguera en la Infancia por Retinopatía del Prematuro”)  Recommendations for Retinopathy of Prematurity screening in at-risk populations  Arch Argent Pediatr. 2008 Feb;106(1):71-6

Sildenafil (Viagra) in Neonatal Pulmonary Hypertension and Severe hypoxemic respiratory failure in the newborn.

  1. Hernando Baquero, Solis A, Freddy Neira, Maria E. Venegas and Augusto Sola: Oral Sildenafil in Infants With Persistent Pulmonary Hypertension of the Newborn: A Pilot Randomized Blinded Study. Pediatrics 2006:117;1077-1083
  2. Baquero, H, Sola, A: Intratracheal Sildenafil in the Newborn With Pulmonary Hypertension. Pediatrics Volume 119, Number 1, January 2007 pages 215-216
  3. Augusto Sola and Hernando Baquero: Oral Sildenafil in Neonatal Medicine: “Tested in adults also used in neonates”. An Pediatr (Barc). 2007;66(2):167-76
  4. Lemus-Varela ML, Sola A , Gómez BC , Zamora AL , Ramos ML, Batista CM, Zúñiga GM: Oral sildenafil citrate lacks genotoxicity and cytotoxicity in a primate model: Callithrix jacchus. J Perinatol. 2006 Jul;26(7):423-7.
  5. PEDIATRICS Volume 119, Number 1, January 2007. Intratracheal Sildenafil in the Newborn With Pulmonary Hypertension. Hernando Baquero, MD Augusto Sola, MD, Division of Neonatology, MANA and Morristown Memorial Hospital, Morristown, NJ 07962

Other recent publications of clinical interest.

  1. Augusto Sola as senior author: Outcome of infants born at 24-26 weeks’ gestation: I. Survival and cost. Obstet Gynecol. 1997;90(5):803-8
  2. Augusto Sola as senior author: Outcome of infants born at 24-26 weeks’ gestation: II. Neurodevelopmental outcome. Obstet Gynecol. 1997;90(5):809-14.
  3. Harrison MR et al Correction of congenital diaphragmatic hernia in utero VIII: Response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg. 1996;31(10):1339-48.
  4. Harrison MR et al Correction of congenital diaphragmatic hernia in utero VII: a prospective trial. J Pediatr Surg. 1997;32(11):1637-42.
  5. Metkus AP, Esserman L, Sola A, Harrison MR, Adzick NS. Cost per anomaly: what does a diaphragmatic hernia cost? J Pediatr Surg. 1995;30(2):226-30
  6. Stringer MD, Sola A, Adzick NS, Harrison MR. Fetal diaphragmatic hernia without visceral herniation. J Pediatr Surg.. 1995;30(9):1264-6.
  7. Sola A, Chow LC. The coming of (gestational) age for preterm infants. J Pediatr. 1999;135 (2 Pt 1):137-9
  8. Renken IO, Sola A, Gooding CA. Direct coronal CT scanning of the neonatal chest. Pediatr Radiol. 1999;29(6):451-4.
  9. Sola A, Farina D. Neonatal respiratory care and infant mortality in emerging countries. Pediatr Pulmonol. 1999 May;27(5):303-4.
  10. First Trial on Synchronized Intermittent Mechanical Ventilation. Augusto Sola PI at UCSF. Randomized multicenter trial comparing synchronized and conventional intermittent mandatory ventilation in neonates. J Pediatr. 1996;128(4):453-63
  11. Sola A, Rogido M. Pulmonary injury in the pre-term neonate. Neonatal Intsv Care, Oct 13(6):60-62, 2001.
  12. Rogido M, Sola A. Ventilación mecánica en el recién nacido de muy bajo peso al nacer. UCIN, 2(1):40-51, 2002
  13. Chow LC, Vanderhal A, Raber J, Sola A. Are tidal volume measurements in neonatal pressure-controlled ventilation accurate? Pediatr Pulmonol. 2002 Sep;34(3):196-202
  14. Wong AF, Sola A. Treatment of peripheral tissue ischemia with topical nitroglycerin ointment in neonates. J Pediatr. 1992;121(6):980-3.
  15. Baserga M, Puri A, Sola A. The Use of Topical Nitroglycerin Ointment to Treat Peripheral Tissue Ischemia Secondary to Arterial Line Complications in Neonates. J Perinatol. 2002;22:416-419
  16. Deulofeut R, Sola A, Lee B, Buchter S, Rahman M, Rogido M. The impact of vaginal delivery in premature infants weighing less than 1,251 grams. Obstet Gynecol 2005;105(3):525-531
  17. Delivery room cardiopulmonary resuscitation of the very preterm infant is associated with adverse short and long term outcomes. R. Deulofeut, A. Sola, B. Lee and M. Rogido Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Emory University, Atlanta, Georgia And MidAtlantic Neonatology and Morristown Memorial Hospital, Morristown, New Jersey An Pediatr (Barc). 2007;66(1):31-7

Abstracts

In addition to the above publications Dr. Sola and his colleagues and trainees present research findings at various research societies like National Pediatric Academic Societies (Society for Pediatric Research, American Pediatric Society), International Societies and Regional Societies.

Below are the research findings submitted to the APS/SPR Annual Meeting for 2008.

  1. Inhibition of cleaved caspase-8 and caspase-3 by cardiotrophin-1 in the neonatal brain following focal cerebral ischemia and in cultured neurons exposed to sodium nitroprusside. Wen TC, Peng H, Rogido M, Sola A.
  2. BAP31, an integral protein of the endoplasmic reticulum, expresses in ischemic cortex and in cleaved Caspase-8 and TUNEL-positive cells. Wen TC, Peng H, Rogido M, Sola A.
  3. Endogenous cannabinoid system activation in neonatal focal cerebral ischemic injury in rat pups. Rogido MR, Martinez Orgado JA, Pazos R, Wen TC, Sola A, Romero J.
  4. Is it possible to improve neonatal survival by uniform implementation of continuous quality care measures? The experience of Cuba. Dominguez F, Duenas E, Sola A.
  5. Patency of the ductus: first clinical consensus of the Ibero-American Society of Neonatology. Golombek S, Sola A, and SIBEN PDA Consensus Group.
  6. Late onset neonatal pulmonary hypertension: Role of persistently prolonged patent ductus? Saldeño YP, Favareto V, Rogido M, Sola A.
  7. Saturation limits and alarm settings in a NICU: What is the sound of one hand clapping? Favareto V, Saldeño YP, Rogido M, Sola A.
  8. Prolonged persistent patent ductus arteriosus: Potential perdurable anomalies in premature infants. Mirpuri J, Sola A, Favareto V, Saldeño YP, Goldsmit G, Fariña D, Lee BH, Schenkman A. Rogido M
  9. Clinical Practice Assessing Problems: Prospective Evaluation of Continuous Positive Airway Pressure in The Early XXI Century. Saldeño YP, Favareto V, Rogido M, Sola A.
  10. Lower SpO2 targets and incidence of patent ductus arteriosus. Castillo A, Deulofeut R, Sola A.
  11. High PaO2 is directly proportional to SpO2 levels 94%-100% in newborns receiving oxygen in the neonatal intensive care unit. Castillo A, Baquero H, Neira F, Alvis R, Critz A, Deulofeut R, Sola A.
  12. A Brief History of the Use of Oxygen in Neonatology. Golombek S, Sola A
  13. What Is The Risk Of Low Pao2 In Newborns Receiving Supplemental Oxygen In The Neonatal Intensive Care Unit When Spo2 Is 85%To93%? Castillo A, Baquero H, Neira F, Alvis R, Critz A, Deulofeut R, Sola A
  14. Neurological Follow-Up (48 Months) Of Patients Treated With Oral Sildenafil For Severe Neonatal Pulmonary Hypertension In Nicu Where iNO Is Not Available Baquero H, Venegas ME, Lorena V, Neira F, Sola A.
  15. Different Approach To The Use Of Intravenous Sodium Bicarbonate In Asphyxia Among European Neonatologists. Saenz P, de Jhong B, Aguar M, Brugada M, Sola A, Vento M
  16. An International Survey On Intravenous Sodium Bicarbonate Use In Neonatology. Saenz P, de Jhong B, Aguar M, Brugada M, Sola A, Vento M

Listed below are some of the many abstracts presented at National Pediatric Academic Societies (Society for Pediatric Research, American Pediatric Society), International Societies and Regional Societies for 2006 and 2007.

  1. A Sola, A Schenkman, L Skolnick, M Rogido: Prevention of retinopathy of prematurity. European Academy of Paediatrics and ESPR, 2006 Oct, page 64
  2. A Castillo, H Baquero, F Neira, R Deulofeut, A Sola: Levels of (Spo2) between 85% and 93% are associated with normoxemia in newborns (NB) receiving oxygen therapy (FiO2>21%) in the neonatal intensive care unit (NICU). EAP and ESPR, 2006, Oct, page 65
  3. Augusto Sola, Ben Lee: Uniform Application of Neonatal Guidelines Without Adequate Evidence: the Illusion of Knowledge? PAS and Eastern SPR Annual Meeting, 2007
  4. A. Castillo, R. Deulofeut and A. Sola: Clinical Practice andSpO2 Technology in the Prevention of ROP in ELBW infants. PAS and Eastern SPR Annual Meeting, 2007
  5. A. Sola: Education in Neonatal oxygenation Has Been Insufficient: A Need for Darning. PAS and Eastern SPR Annual Meeting, 2007
  6. Hypothermia increases erythropoietin receptor expression in neurons through an adenosine and ATP signaling pathway. Moore J, Peng H, Wen TC, Rogido M, Sola A.
  7. Avoiding hyperoxemia during neonatal resuscitation: Time to response of different SpO2 monitors. Baquero H, Sola A
  8. Clinical practice and SpO2 technology in the prevention of ROP in ELBW infants. Castillo A, Sola A
  9. TOI (Tissue Oxygenation Index) and arterial saturation (SaO2) in extremely low birth weight infants: Are they associated? Bravo C, Cabanas F, Sola A, Madero R, Gaya F, Quero J, Pellicer A.