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Augusto Sola, M.D.

Publicaciones

El Dr. Sola escribió dos libros de neonatología en Español.

Books

El primer libro,“Cuidados Intensivos Neonatales, Fisiopatología y Terapéutica,” se editó en 1987. En la era donde no existía el fax, ni Internet, ni los e-mails, este libro fue extremadamente importante para el cuidado del recién nacido, principalmente en los países de Latino América. El segundo libro, se editó en dos tomos y lo escribió junto a su esposa, Marta Rogido MD. Su titulo es “Cuidados Especiales del Feto y el Recién Nacido,” y se publicó en el año 2001 y actualmente está agotado.

El Dr. Sola también tiene varios capítulos en libros neonatales y de pediatría, escritos en USA, Argentina, Chile, México y en otras naciones. Dentro de la Medicina Neonatal, tiene más de 80 publicaciones tanto sobre la investigación como en asuntos clínicos. Se pueden ver en su CV. Sus publicaciones más recientes se focalizaron en tres temas:

  1. Mecanismos de daño y de protección en el cerebro en desarrollo.
  2. Mejorar los resultados cambiando la práctica en la administración del oxígeno y en el monitoreo del oxímetro de pulso
  3. Insuficiencia respiratoria hipoxémica severa en el recién nacido, la exploración del uso oral del sildenafil (Viagra).

Las más importantes publicaciones referidas a los temas mencionados anteriormente incluyen:

A ser publicados en los proximos meses

  1. “Animal Models of Neonatal Stroke and Response to Erythropoietin and Cardiotrophin-1″. International Journal of Developmental Neuroscience, 2007 Sep 12; [Epub ahead of print]. It will be published in the Special Issue on Perinatal Hypoxia in January 2008
  2. Pulse Oximetry Saturation Levels and Arterial Oxygen Tension Values in Newborns Receiving Oxygen Therapy in the Neonatal Intensive Care Unit: Is 85% to 93% an Acceptable Range? Castillo A, Sola A. To be published in PEDIATRICS in May 2008.
  3. Iron, oxidation and preterm infants. A. Sola and Marta Rogido. To be published in Journal of Pediatrics
  4. Clinical Practices in Neonatal Oxygenation: Where have we failed? What can we do? A. Sola Yolanda Pérez Saldeño, Verónica Favareto to be published in Journal of Perinatology, May 2008
  5. Oxygen during neonatal anesthesia: Friend or Foe? A. Sola To be published in Paediatric Anaesthesia, Current Opinion in Anesthesiology

Editoriales

  1. Postnatal Steroids: Short-term gain, long-term pain? Neil N. Finer, MD, Alissa Craft, DO, MBA, Yvonne E. Vaucher, MD, MPH, Reese H. Clark, MD and Augusto Sola MD J Pediatr 2000:137:9-13
  2. An evident view of evidence-based practice in perinatal medicine: absence of evidence is not evidence of absence. Augusto Sola, Fernando Dominguez Dieppa, Marta R. Rogido J Pediatr (Rio J). 2007;83(5): 395-414. (Evidence-based medicine, number needed to treat, randomized trials, outcome variables, treatment effects, critical reading, statistical significance.)
  3. Sola, A. Turn off the lights and the oxygen, when not needed: phototherapy and oxidative stress in the neonate. J Pediatr (Rio J). 2007 Jul-Aug;83(4):293-6.Click here to read

Mecanismos de daño y de protección en el cerebro en desarrollo.

  1. Sola A, Piecuch R. Prevalence of cerebral palsy: estimations, calculations and neonatal care. Pediatrics. 1994 Jan;93(1):152-3.
  2. Sola A Berrios M, Gregory A, Ferriero D. Fructose-1,6-bisphosphate after hypoxic ischemic injury is protective to the neonatal rat brain. Brain Res. 1996 25;741(1-2):294-9
  3. Westmark KD, Barkovich AJ, Sola A, Ferriero D, Partridge JC. Patterns and implications of MR contrast enhancement in perinatal asphyxia: a preliminary report. AJNR Am J Neuroradiol. 1995;16(4):685-92.
  4. Barkovich AJ, Westmark K, Partridge C, Sola A, Ferriero DM. Perinatal asphyxia: MR findings in the first 10 days. AJNR Am J Neuroradiol. 1995;16(3):427-38.
  5. Barkovich AJ. MR contrast enhancement of the normal neonatal brain. AJNR Am J Neuroradiol. 1997;18(9):1713-7
  6. Van Bel F, Sola A, Roman C, Rudolph AM. Role of nitric oxide in the regulation of the cerebral circulation in the lamb fetus during normoxemia and hypoxemia. Biol Neonate. 1995;68(3):200-10
  7. Van Bel, Sola A, Rudolph AR. Perinatal regulation of the cerebral circulation: role of nitric oxide and prostaglandins. Pediatr Res. 1997;42(3):299-304
  8. Barkovich AJ. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. AJNR Am J Neuroradiol. 1998;19(1):143-9
  9. Finer N, Craft A, Vaucher Y, Clark R, Sola A. Postnatal Steroids: Short Term Gain, Long Term Pain? J Pediatr, 2000 July; 137 (1): 9-13.
  10. Gressens P, Sola A. Environmental factors and disturbances of brain development. Semin Neonatol. 200;6(2):185-94.
  11. Gressens P, Rogido M, Paindaveine B, Sola A. The Impact of Frequent Neonatal Intensive Care Practices on the Developing Brain. J Pediatr,140:646-653, 2002.
  12. Rogido, M, Husson I, Bonnier C, Lallemand MC, Merienne C, Gregory GA, Sola A, Gressens P. Fructose-1, 6 biosphate prevents excitotoxic neuronal cell death in the neonatal mouse brain. Brain Res Dev Brain Res, Feb;140:287-297, 2003.
  13. Baserga MC, Gregory GA, Sola A. Cerebrovascular Response in Small Preterm Infants during Routine Nursery Gavage Feedings. Biol Neonate, 83:12-18, 2003.
  14. Wen TC, Rogido M, Gressens P, Sola A. A reproducible experimental model of focal cerebral ischemia in the neonatal rat. Brain Research Protocols, 13:76-83, 2004.
  15. Wen, TC, Rogido, M, Genetta, T, Sola, A. Permanent focal cerebral ischemia activates erythropoietin receptor I in the neonatal rat brain. Neurosci Lett, 355(3):165-168, 2004.
  16. Valerie Boss, Augusto Sola, Tong-Chun Wen, Michael J. Decker. Mild Intermittent Hypoxis Does Not Induce Stress Responses in the Neonatal Rat Brain. Biology of the Neonate 2005;88:313-320
  17. Sola A, Rogido M, Lee B, Genetta T, Wen TC. Erythropoietin after Focal Cerebral Ischemia Activates the Jaanus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats. Pediatr Res, Apr;57(4):481-7, 2005.
  18. Sola A, Wen T-C, Hamrick S, Ferriero DM. Potential for Protection and Repair following Injury to the Developing Brain: A Role for Erythropoietin? Pediatr Res, May; 57(5), part 2:110R-117R, 2005.
  19. Baserga M, Bertolotto C, Sola A. Different Doses of Dopamine have heterogeneous effects on Cerebral Hemodynamics and Dopamine Receptors in Young Rabbits as measured with Near-Infrared Spectroscopy. Biol Neonate, Jan 14;87(4):229-235, 2005.
  20. Deulofeut R, Sola A. Injury to the Developing Brain in Term and Pre-Term Infants: Mechanisms of Injury and Potential for Prevention and Repair. Journal of The Arab Neonatology Forum, 2: 34-47; 2005.
  21. Thomas Genetta, Ben H. Lee, Augusto Sola. Low doses of ethanol and hypoxia administered together act synergistically to promote the death of cortical neurons. Journal of Neuroscience Research, 2006;851(1): 131-138
  22. Lee Ben H., Wen Tong-Chun, Rogido Marta, Sola Augusto. Glucocorticoid Receptor Expression in the Cortex of the Neonatal Rat Brain with and without Focal Cerebral Ischemia. Neonatology 2007;91:12-19
  23. Baud Oliver, Sola Augusto Corticosteroids in perinatal medicine: How to imporve outcomes without affecting the developing brain?
  24. Gender Differences in Long-Term Beneficial Effects of Erythropoietin Given After Neonatal Stroke in Postnatal Day-7 Rats. T.C. Wen, M. Rogido, H. Peng, T. Genetta, J. Moore and A. Sola Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA Neuroscience 139 (2006) 803-811

El oxígeno y sus consecuencias. Mejorar los resultados cambiando la práctica en la administración del oxígeno y en el monitoreo del oxímetro de pulso.

  1. Flynn JT, Sola A, Good WV, Phibbs RH. Screening for retinopathy of prematurity — a problem solved? Pediatrics. 1995 May;95(5):755-7
  2. Chow LC, Wright KW, Sola A: Can changes in clinical practice decrease the incidence of severe retinopathy of Prematurity in Very Low Birth Weight Infants? Pediatrics, Feb: 111(2):339-45, 2003.
  3. Sola A, Chow, L, Rogido M: Retinopathy of Prematurity and Oxygen Therapy: A Changing Relationship. An Pediatr (Barc), Jan;62(1):48-63, 2005.
  4. Sola A, Chow L, Rogido M: Pulse oximetry in neonatal care in 2005. A comprehensive state of the art review. An Pediatr (Barc), Mar;62(3):266-281, 2005.
  5. Augusto Sola, MD, Richard Deulofeut, MD, MPH: Oxygen and oxygenation in the delivery room. The Journal of Pediatrics, Volume 148, Issue 4, Pages 564-565 (April 2006
  6. Deulofeut R, Critz A, Adams-Chapman I, Sola A: Avoiding hyperoxia in infants< 1250 g is associated with improved short-and long-term outcomes. Journal of Perinatology (2006) 26, 700-705
  7. Sola A, Rogido MR, Deulofeut R.: Oxygen as a neonatal health hazard: Call for Détente in Clinical Practice. Acta Paediatr. 2007 Jun;96(6):798-800.
  8. Treatment-by-gender effect when aiming to avoid hyperoxia in preterm infants in the NICU. Richard Deulofeut, Golde Dudell, Augusto Sola. Acta Paediatr. 2007 Jul;96(7):990-4.
  9. Retinopathy of prematurity in the XXI century in a developing country: an emergency that should be resolved. Bouzas L, Bauer G, Novali L, Dilger A, Galina L, Falbo J, Díaz González L, Manzitti J, Sola A. An Pediatr (Barc). 2007 Jun;66(6):551-8.
  10. Ophthalmologic and neonatal guidelines for ROP screening and treatment in Latin American Countries (October/2007) VISION 2020 The Right to Sight AMERICAS

Sildenafil (Viagra) en la Hipertensión Pulmonar Neonatal y la insuficiencia respiratoria hipoxémica severa en el recién nacid.

  1. Hernando Baquero, Solis A, Freddy Neira, Maria E. Venegas and Augusto Sola: Oral Sildenafil in Infants With Persistent Pulmonary Hypertension of the Newborn: A Pilot Randomized Blinded Study. Pediatrics 2006:117;1077-1083
  2. Baquero, H, Sola, A: Intratracheal Sildenafil in the Newborn With Pulmonary Hypertension. Pediatrics Volume 119, Number 1, January 2007 pages 215-216
  3. Augusto Sola and Hernando Baquero: Oral Sildenafil in Neonatal Medicine: “Tested in adults also used in neonates”. An Pediatr (Barc). 2007;66(2):167-76
  4. Lemus-Varela ML, Sola A , Gómez BC , Zamora AL , Ramos ML, Batista CM, Zúñiga GM: Oral sildenafil citrate lacks genotoxicity and cytotoxicity in a primate model: Callithrix jacchus. J Perinatol. 2006 Jul;26(7):423-7.
  5. PEDIATRICS Volume 119, Number 1, January 2007. Intratracheal Sildenafil in the Newborn With Pulmonary Hypertension. Hernando Baquero, MD Augusto Sola, MD, Division of Neonatology, MANA and Morristown Memorial Hospital, Morristown, NJ 07962

Otras recientes publicaciones de interés clínico.

  1. Augusto Sola as senior author: Outcome of infants born at 24-26 weeks’ gestation: I. Survival and cost. Obstet Gynecol. 1997;90(5):803-8
  2. Augusto Sola as senior author: Outcome of infants born at 24-26 weeks’ gestation: II. Neurodevelopmental outcome. Obstet Gynecol. 1997;90(5):809-14.
  3. Harrison MR et al Correction of congenital diaphragmatic hernia in utero VIII: Response of the hypoplastic lung to tracheal occlusion. J Pediatr Surg. 1996;31(10):1339-48.
  4. Harrison MR et al Correction of congenital diaphragmatic hernia in utero VII: a prospective trial. J Pediatr Surg. 1997;32(11):1637-42.
  5. Metkus AP, Esserman L, Sola A, Harrison MR, Adzick NS. Cost per anomaly: what does a diaphragmatic hernia cost? J Pediatr Surg. 1995;30(2):226-30
  6. Stringer MD, Sola A, Adzick NS, Harrison MR. Fetal diaphragmatic hernia without visceral herniation. J Pediatr Surg.. 1995;30(9):1264-6.
  7. Sola A, Chow LC. The coming of (gestational) age for preterm infants. J Pediatr. 1999;135 (2 Pt 1):137-9
  8. Renken IO, Sola A, Gooding CA. Direct coronal CT scanning of the neonatal chest. Pediatr Radiol. 1999;29(6):451-4.
  9. Sola A, Farina D. Neonatal respiratory care and infant mortality in emerging countries. Pediatr Pulmonol. 1999 May;27(5):303-4.
  10. First Trial on Synchronized Intermittent Mechanical Ventilation. Augusto Sola PI at UCSF. Randomized multicenter trial comparing synchronized and conventional intermittent mandatory ventilation in neonates. J Pediatr. 1996;128(4):453-63
  11. Sola A, Rogido M. Pulmonary injury in the pre-term neonate. Neonatal Intsv Care, Oct 13(6):60-62, 2001.
  12. Rogido M, Sola A. Ventilación mecánica en el recién nacido de muy bajo peso al nacer. UCIN, 2(1):40-51, 2002
  13. Chow LC, Vanderhal A, Raber J, Sola A. Are tidal volume measurements in neonatal pressure-controlled ventilation accurate? Pediatr Pulmonol. 2002 Sep;34(3):196-202
  14. Wong AF, Sola A. Treatment of peripheral tissue ischemia with topical nitroglycerin ointment in neonates. J Pediatr. 1992;121(6):980-3.
  15. Baserga M, Puri A, Sola A. The Use of Topical Nitroglycerin Ointment to Treat Peripheral Tissue Ischemia Secondary to Arterial Line Complications in Neonates. J Perinatol. 2002;22:416-419
  16. Deulofeut R, Sola A, Lee B, Buchter S, Rahman M, Rogido M. The impact of vaginal delivery in premature infants weighing less than 1,251 grams. Obstet Gynecol 2005;105(3):525-531
  17. Delivery room cardiopulmonary resuscitation of the very preterm infant is associated with adverse short and long term outcomes. R. Deulofeut, A. Sola, B. Lee and M. Rogido Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Emory University, Atlanta, Georgia And MidAtlantic Neonatology and Morristown Memorial Hospital, Morristown, New Jersey An Pediatr (Barc). 2007;66(1):31-7

Ademas de lo anterior el Dr Sola sus colegas y medicos en entrenamiento presentan sus hallazgos en diversas sociedades de investigacion. A continuacion estan solo algunos trabajos presentados en Reuniones Academicas (Society for Pediatric Research, American Pediatric Society y de Sociedades Internacionales) del 2006 y 2007.

A continuacion estan los trabajos enviados a la reunion anual de la Sociedad Americana de Pediatria (APS) y la Sociedad de Investigacion Pediatrica de EEUU(SPR) del 2008.

  1. Inhibition of cleaved caspase-8 and caspase-3 by cardiotrophin-1 in the neonatal brain following focal cerebral ischemia and in cultured neurons exposed to sodium nitroprusside. Wen TC, Peng H, Rogido M, Sola A.
  2. BAP31, an integral protein of the endoplasmic reticulum, expresses in ischemic cortex and in cleaved Caspase-8 and TUNEL-positive cells. Wen TC, Peng H, Rogido M, Sola A.
  3. Endogenous cannabinoid system activation in neonatal focal cerebral ischemic injury in rat pups. Rogido MR, Martinez Orgado JA, Pazos R, Wen TC, Sola A, Romero J.
  4. Is it possible to improve neonatal survival by uniform implementation of continuous quality care measures? The experience of Cuba. Dominguez F, Duenas E, Sola A.
  5. Patency of the ductus: first clinical consensus of the Ibero-American Society of Neonatology. Golombek S, Sola A, and SIBEN PDA Consensus Group.
  6. Late onset neonatal pulmonary hypertension: Role of persistently prolonged patent ductus? Saldeño YP, Favareto V, Rogido M, Sola A.
  7. Saturation limits and alarm settings in a NICU: What is the sound of one hand clapping? Favareto V, Saldeño YP, Rogido M, Sola A.
  8. Prolonged persistent patent ductus arteriosus: Potential perdurable anomalies in premature infants. Mirpuri J, Sola A, Favareto V, Saldeño YP, Goldsmit G, Fariña D, Lee BH, Schenkman A. Rogido M
  9. Clinical Practice Assessing Problems: Prospective Evaluation of Continuous Positive Airway Pressure in The Early XXI Century. Saldeño YP, Favareto V, Rogido M, Sola A.
  10. Lower SpO2 targets and incidence of patent ductus arteriosus. Castillo A, Deulofeut R, Sola A.
  11. High PaO2 is directly proportional to SpO2 levels 94%-100% in newborns receiving oxygen in the neonatal intensive care unit. Castillo A, Baquero H, Neira F, Alvis R, Critz A, Deulofeut R, Sola A.
  12. A Brief History of the Use of Oxygen in Neonatology. Golombek S, Sola A
  13. What Is The Risk Of Low Pao2 In Newborns Receiving Supplemental Oxygen In The Neonatal Intensive Care Unit When Spo2 Is 85%To93%? Castillo A, Baquero H, Neira F, Alvis R, Critz A, Deulofeut R, Sola A
  14. Neurological Follow-Up (48 Months) Of Patients Treated With Oral Sildenafil For Severe Neonatal Pulmonary Hypertension In Nicu Where iNO Is Not Available Baquero H, Venegas ME, Lorena V, Neira F, Sola A.
  15. Different Approach To The Use Of Intravenous Sodium Bicarbonate In Asphyxia Among European Neonatologists. Saenz P, de Jhong B, Aguar M, Brugada M, Sola A, Vento M
  16. An International Survey On Intravenous Sodium Bicarbonate Use In Neonatology. Saenz P, de Jhong B, Aguar M, Brugada M, Sola A, Vento M